Recombinant VWF antibody (AA 1150-1250)

Catalog No. ABIN7859085

The Rabbit Monoclonal anti-VWF antibody is suitable to detect VWF in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant VWF antibody (AA 1150-1250) (ABIN7859085)

Target: VWF (Von Willebrand Factor (VWF))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This VWF antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: VWF-7979R

Product Details anti-VWF Antibody

Binding Specificity: AA 1150-1250

Purpose: Recombinant von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody

Specificity: Human von Willebrand factor (VWF or factor VIII-related antigen) is a 309 kDa multimeric plasma glycoprotein, important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Von Willebrand factor also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin. IHC results aid in the classification of acute myeloid leukemia FAB type M7, angiosarcoma and epithelioid hemangioendothelioma.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1150-1250) of human vWF protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for VWF

Target: VWF (Von Willebrand Factor (VWF))

Alternative Name: von Willebrand Factor

Background:

Coagulation Factor VIII, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD)

Human tonsil.

Molecular Weight: 250kDa

Gene ID: 7450, 440848

UniProt: P04275