APOH antibody (AA 145-345)

Catalog No. ABIN7865078

The Mouse Monoclonal anti-APOH antibody is suitable to detect APOH in samples from Human. It has been validated for IHC.

Quick Overview for APOH antibody (AA 145-345) (ABIN7865078)

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOH antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: APOH-3705

Product Details anti-APOH Antibody

Binding Specificity: AA 145-345

Purpose: Apolipoprotein H / APOH Antibody

Specificity: Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa145-345) of human APOH protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for APOH

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Alternative Name: Apolipoprotein H

Background:

Activated protein C-binding protein, Anticardiolipin cofactor, APC inhibitor, Apo-H, apolipoprotein H (beta-2-glycoprotein I), B2G1, B2GP1, B2GPI, Beta 2 glycoprotein I precursor, Beta(2)GPI, BG, Glycoprotein 1, beta-2,

Human liver.

Molecular Weight: 38kDa

Gene ID: 350, 445358

UniProt: P02749