GBX2 antibody (AA 150-350)

Catalog No. ABIN7864724

The Mouse Monoclonal anti-GBX2 antibody (Clone GBX2-7235) (ABIN7864724) specifically detects GBX2 in IHC. The antibody is reactive with Human samples.

Quick Overview for GBX2 antibody (AA 150-350) (ABIN7864724)

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GBX2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: GBX2-7235

Product Details anti-GBX2 Antibody

Binding Specificity: AA 150-350

Purpose: GBX2 / Gastrulation Brain Homeobox 2 Antibody

Specificity: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis, GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa150-350) of human GBX2 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for GBX2

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Alternative Name: GBX2

Background:

Gastrulation and brain-specific homeobox protein 2, Gastrulation brain homeobox 2, Homeobox protein GBX2, Homeobox protein STRA7, Mmoxa

Human placenta or brain.

Molecular Weight: 37kDa

Gene ID: 2637, 184945

Pathways: Dopaminergic Neurogenesis