APOE antibody (AA 19-119)

Catalog No. ABIN7859312

This Mouse Monoclonal antibody specifically detects APOE in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for APOE antibody (AA 19-119) (ABIN7859312)

Target: APOE (Apolipoprotein E (APOE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: APOE-3673

Product Details anti-APOE Antibody

Binding Specificity: AA 19-119

Purpose: Apolipoprotein E / APOE Antibody

Specificity: In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Human recombinant APOE protein fragment (around aa19-119) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for APOE

Target: APOE (Apolipoprotein E (APOE))

Alternative Name: Apolipoprotein E

Background:

AD2, Apo-E, Apolipoprotein E3, Apoprotein, LDLCQ5, LPG

Human liver|spleen or kidney tissue.

Molecular Weight: 36kDa

Gene ID: 348, 654439

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism