SLAMF7 antibody (AA 200-335)

Catalog No. ABIN7859436

The Mouse Monoclonal anti-SLAMF7 antibody is suitable to detect SLAMF7 in samples from Human. It has been validated for IHC.

Quick Overview for SLAMF7 antibody (AA 200-335) (ABIN7859436)

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SLAMF7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: SLAMF7-13123

Product Details anti-SLAMF7 Antibody

Binding Specificity: AA 200-335

Purpose: SLAMF7 / CS1 / CD319 (NK Cell Marker) Antibody

Specificity: CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLC and PI 3K. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-335) of human SLAMF7 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SLAMF7

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Alternative Name: SLAMF7

Background:

19A, 19A24 protein, CD2 like receptor activating cytotoxic cells, CD2 subset 1, CRACC, CS1, Membrane protein FOAP 12, Novel LY9 (lymphocyte antigen 9) like protein, Protein 19A, SLAM family member 7

Human tonsil, lymph node or testis.

Molecular Weight: 37kDa

Gene ID: 57823, 517265

UniProt: Q9NQ25