AMBP antibody (AA 200-353)

Catalog No. ABIN7859443

The Mouse Monoclonal anti-AMBP antibody (Clone AMBP-4536) (ABIN7859443) specifically detects AMBP in IHC. The antibody is reactive with Human samples.

Quick Overview for AMBP antibody (AA 200-353) (ABIN7859443)

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AMBP antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AMBP-4536

Product Details anti-AMBP Antibody

Binding Specificity: AA 200-353

Purpose: AMBP (Alpha 1 Microglobulin) / Bikunin Antibody

Specificity: The AMBP (±-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated ±-1-Microglobulin and Bikunin. ±-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, ±-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-±-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike ±-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-353) of human AMBP protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for AMBP

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Alternative Name: AMBP

Background:

A1M, Alpha 1 microglobulin/bikunin precursor, Alpha 1 microglycoprotein, Bikunin, Complex-forming glycoprotein heterogeneous in charge, EDC1, Growth inhibiting protein 19, HCP, HI30, IATIL, ITI, ITI-LC, ITIL, Microglobulin (alpha 1), Protein AMBP, Protein HC, Trypstatin, Uristatin, Uronic-acid-rich protein, UTI

Human liver or placenta.

Molecular Weight: 30kDa

Gene ID: 259, 436911