Recombinant T-Box 19 antibody (AA 235-435)

Catalog No. ABIN7859600

This Rabbit Monoclonal antibody specifically detects T-Box 19 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant T-Box 19 antibody (AA 235-435) (ABIN7859600)

Target: T-Box 19 (TBX19)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This T-Box 19 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TBXT-7711R

Product Details anti-T-Box 19 Antibody

Binding Specificity: AA 235-435

Purpose: Recombinant TBXT / T-box transcription factor T / Brachyury Antibody

Specificity: The T-box gene family consists of members that share a unique DNA binding domain. The best characterized T-box (Tbx) gene, brachyury or T, encodes a transcription factor that plays an important role in early vertebrate development. Tbx genes are a family of developmental regulators with more than 20 members recently identified among invertebrates and vertebrates. Mutations in Tbx genes have been found to cause several human diseases. The understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/brachyury protein, which is a transcription activator. The T-domain is a highly conserved DNA-binding motif originally defined in brachyury and characteristic of the Tbx family of transcription factors. The murine brachyury (T) gene is required in posterior mesoderm formation and axial development. Mutant embryos lacking T gene function are deficient in notochord differentiation and posterior mesoderm formation, but develop anterior mesoderm.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 235-435) of human TBXT protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for T-Box 19

Target: T-Box 19 (TBX19)

Alternative Name: TBXT

Background:

BRAC_HUMAN, Brachyury homolog, Brachyury protein, Bry, MGC104817, Protein T, SAVA, T, T brachyury homolog, T brachyury transcription factor, T Protein, T, brachyury homolog (mouse), TFT, Transcription factor T

Human chordoma tissue.

Molecular Weight: 47kDa

Gene ID: 6862, 389457

UniProt: O15178