Fodrin (AA 2351-2475) antibody

Catalog No. ABIN7863429

The Mouse Monoclonal anti-Fodrin antibody is suitable to detect Fodrin in samples from Human. It has been validated for IHC.

Quick Overview for Fodrin (AA 2351-2475) antibody (ABIN7863429)

Target: Fodrin

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Clone: SPTAN1-3505

Product Details

Binding Specificity: AA 2351-2475

Purpose: Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody

Specificity: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous °™ and æ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin °™ I and spectrin æ I are present in erythrocytes, whereas spectrin °™ II (also designated fodrin °™) and spectrin æ II (also designated fodrin æ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin °™ II, a neuronal cytoskeleton protein.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary))

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details

Target: Fodrin

Background:

Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2

Human colon or kidney tissues (IHC).

Molecular Weight: 240kDa

Gene ID: 6709, 372331

UniProt: Q13813