CHGB antibody (AA 250-450)

Catalog No. ABIN7864634

This Mouse Monoclonal antibody specifically detects CHGB in IHC. It exhibits reactivity toward Human.

Quick Overview for CHGB antibody (AA 250-450) (ABIN7864634)

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CHGB antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: CHGB-7756

Product Details anti-CHGB Antibody

Binding Specificity: AA 250-450

Purpose: Chromogranin B / CHGB (Neuroendocrine Marker) Antibody

Specificity: Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa250-450) of human CHGB protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CHGB

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Alternative Name: Chromogranin B

Background:

CCB peptide, Cg B, CgB, Chgb, SCG1, SCG1_HUMAN, Secretogranin 1, Secretogranin B, Secretogranin I, SgI

Human adrenal gland, kidney, pancreas, cerebellum or stomach.

Molecular Weight: 76/110kDa

Gene ID: 1114, 516874

UniProt: P05060