CDH6 antibody (AA 250-450)

Catalog No. ABIN7865425

This Mouse Monoclonal antibody specifically detects CDH6 in IHC. It exhibits reactivity toward Human.

Quick Overview for CDH6 antibody (AA 250-450) (ABIN7865425)

Target: CDH6 (K-Cadherin (CDH6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDH6 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: CDH6-9347

Product Details anti-CDH6 Antibody

Binding Specificity: AA 250-450

Purpose: Cadherin-6 (CDH6) / K-Cadherin Antibody

Specificity: This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. This protein may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 250-450) of human Cadherin 6 protein (CDH6) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CDH6

Target: CDH6 (K-Cadherin (CDH6))

Alternative Name: Cadherin-6

Background:

Cadherin-6, CDH6, CAD6, KCAD,

Human kidney or renal cell carcinoma.

Molecular Weight: 130kDa

Gene ID: 1004, 124776

UniProt: P55285

Pathways: Cell-Cell Junction Organization