Recombinant SOX11 antibody (AA 300-400)

Catalog No. ABIN7863416

The Rabbit Monoclonal anti-SOX11 antibody (Clone SOX11-3235R) (ABIN7863416) specifically detects SOX11 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant SOX11 antibody (AA 300-400) (ABIN7863416)

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SOX11 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: SOX11-3235R

Product Details anti-SOX11 Antibody

Binding Specificity: AA 300-400

Purpose: Recombinant SOX11 (Mantle Cell Lymphoma Marker) Antibody

Specificity: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa300-400) of human SOX11 protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SOX11

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Alternative Name: SOX11

Background:

SOX11, SRY (sex determining region Y) box 11, SRY related HMG box gene 11, Transcription factor SOX-11

A431 or Y79 cells. Human cervix or mantle cell lymphoma (MCL).

Molecular Weight: 47kDa

Gene ID: 6664, 432638

UniProt: P35716

Pathways: Tube Formation