Transferrin antibody (AA 311-445)

Catalog No. ABIN7859897

This Mouse Monoclonal antibody specifically detects Transferrin in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Transferrin antibody (AA 311-445) (ABIN7859897)

Target: Transferrin (TF)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: TF-4799

Product Details anti-Transferrin Antibody

Binding Specificity: AA 311-445

Purpose: Transferrin (Early Marker of Oligodendrocytes) Antibody

Specificity: Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 311-445) of human TF protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Transferrin

Target: Transferrin (TF)

Alternative Name: Transferrin

Background:

Apotransferrin, Beta-1 metal-binding globulin, Serotransferrin, Siderophilin, TF, TFQTL1, Transferrin

Human liver or hepatocellular carcinoma.

Molecular Weight: 79kDa

Gene ID: 7018, 518267

UniProt: P02787

Pathways: Transition Metal Ion Homeostasis