Vitamin D-Binding Protein antibody (AA 35-175)

Catalog No. ABIN7859949

The Mouse Monoclonal anti-Vitamin D-Binding Protein antibody is suitable to detect Vitamin D-Binding Protein in samples from Human. It has been validated for IHC.

Quick Overview for Vitamin D-Binding Protein antibody (AA 35-175) (ABIN7859949)

Target: Vitamin D-Binding Protein (GC)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Vitamin D-Binding Protein antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: VDBP-4482

Product Details anti-Vitamin D-Binding Protein Antibody

Binding Specificity: AA 35-175

Purpose: GC Vitamin D Binding Protein Antibody

Specificity: Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 35-175) of human GC protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Vitamin D-Binding Protein

Target: Vitamin D-Binding Protein (GC)

Alternative Name: GC Vitamin D Binding Protein

Background:

DBP/GC, Gc globulin, GRD3, Group specific component vitamin D binding protein, hDBP, VDB, VDBG, VDBP, Vitamin D binding alpha globulin, Vitamin D-binding protein

Human liver, kidney or pancreas.

Molecular Weight: 53kDa.

Gene ID: 2638, 418497

UniProt: P02774

Pathways: Metabolism of Steroid Hormones and Vitamin D, Monocarboxylic Acid Catabolic Process