Recombinant Keratin 10 antibody (AA 384-584)

Catalog No. ABIN7864240

This Mouse Monoclonal antibody specifically detects Keratin 10 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant Keratin 10 antibody (AA 384-584) (ABIN7864240)

Target: Keratin 10 (KRT10)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Keratin 10 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RKRT10-6923

Product Details anti-Keratin 10 Antibody

Binding Specificity: AA 384-584

Purpose: Recombinant Cytokeratin 10 (Suprabasal Epithelial Marker) Antibody

Specificity: This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more differentiated parts.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa384-584) of human KRT10 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Keratin 10

Target: Keratin 10 (KRT10)

Alternative Name: Cytokeratin 10

Background:

BCIE, BIE, EHK, Keratin Type I Cytoskeletal 10, KRT10

Human esophagus or tonsil.

Molecular Weight: 56.5kDa

Gene ID: 3858, 99936

UniProt: P13645