GLN1 antibody (AA 50-250)

Catalog No. ABIN7864741

The Mouse Monoclonal anti-GLN1 antibody (Clone GLUL-6601) (ABIN7864741) specifically detects GLN1 in WB and IHC. The antibody is reactive with Human, Dog, Horse and Cat samples.

Quick Overview for GLN1 antibody (AA 50-250) (ABIN7864741)

Target: GLN1 (Glutamine Synthetase (GLN1))

Reactivity: Human, Dog, Horse, Cat

Host: Mouse

Clonality: Monoclonal

Conjugate: This GLN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: GLUL-6601

Product Details anti-GLN1 Antibody

Binding Specificity: AA 50-250

Purpose: Glutamine Synthetase / GLUL Antibody

Specificity: Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 50-250) of human GLUL protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for GLN1

Target: GLN1 (Glutamine Synthetase (GLN1))

Alternative Name: Glutamine Synthetase

Background:

cell proliferation-inducing protein 59, GLUL, Glutamate ammonia ligase, GS, PIG43, PIG59, Glutamate decarboxylase, glutamine synthase, Glutamine synthetase, glutamine synthetase I, Proliferation inducing protein 43, GLNA, GLNS

Human brain|stomach or thyroid. A-431 or Y79 cells.

Molecular Weight: 42kDa

Gene ID: 2752, 518525

Pathways: Positive Regulation of Peptide Hormone Secretion