Recombinant ACE2 antibody (AA 705-805)

Catalog No. ABIN7863321

This Rabbit Monoclonal antibody specifically detects ACE2 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant ACE2 antibody (AA 705-805) (ABIN7863321)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ACE2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: ACE2-6788R

Product Details anti-ACE2 Antibody

Binding Specificity: AA 705-805

Purpose: Recombinant ACE2 / Angiotensin | Converting Enzyme 2 Antibody

Specificity: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa705-805) of human ACE2 (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Alternative Name: ACE2

Background:

ACE related carboxypeptidase, ACE2, ACEH, Angiotensin converting enzyme 2, Angiotensin converting enzyme like protein, Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2, Angiotensin-converting enzyme homolog, EC 3.4.17, DKFZP434A014, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2

Heart, Human kidney, testis or small intestine.

Molecular Weight: 92kDa

Gene ID: 59272, 178098

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour