Inhibin alpha antibody (AA 73-96)

Catalog No. ABIN7863027

The Mouse Monoclonal anti-Inhibin alpha antibody (Clone INHA-4265) (ABIN7863027) specifically detects Inhibin alpha in IHC. The antibody is reactive with Human samples.

Quick Overview for Inhibin alpha antibody (AA 73-96) (ABIN7863027)

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Inhibin alpha antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: INHA-4265

Product Details anti-Inhibin alpha Antibody

Binding Specificity: AA 73-96

Purpose: Inhibin, alpha (INHA) (Gonadal Cell Marker) Antibody

Specificity: It recognizes a 47 kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same °™ subunit, covalently linked to 1 of 2 distinct subunits, æ-°™ or æ- æ. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor æ (TFG æ) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. Inhibin antibody is also used to make the differential diagnosis of intra-uterine vs. ectopic pregnancy in endometrial curetting.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: A synthetic peptide (around aa 73-96) of α-subunit of human inhibin A protein (exact sequence is proprietary)

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Alternative Name: Inhibin, alpha

Background:

A inhibin subunit, IHA, inhA, Inhibin alpha chain, Inhibin alpha subunit

Human prostate or testis.

Molecular Weight: 47kDa

Gene ID: 3623, 407506

UniProt: P05111

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion