Recombinant MUM1 antibody (C-Term)

Catalog No. ABIN7860711

The Rabbit Monoclonal anti-MUM1 antibody is suitable to detect MUM1 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant MUM1 antibody (C-Term) (ABIN7860711)

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MUM1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MUM1-8560R

Product Details anti-MUM1 Antibody

Binding Specificity: C-Term

Purpose: Recombinant MUM1 / IRF4 (Transcription Factor) Antibody

Specificity: MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (corresponding to C-terminal) of IRF4 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10  mM PBS with 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for MUM1

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Alternative Name: MUM1

Background:

Interferon regulatory factor 4, IRF 4, LSIRF, Lymphocyte specific interferon regulatory factor, Multiple myeloma oncogene 1, MUM1, NFEM5, PU.1 interaction partner, Sfpi1/PU.1 interaction partner, Transcriptional activator PIP

Human tonsil or diffuse large B-cell lymphoma (DLBCL).

Molecular Weight: 52kDa

Gene ID: 3662, 401013

UniProt: Q15306

Pathways: Chromatin Binding