AMH antibody (C-Term)

Catalog No. ABIN7860738

The Mouse Monoclonal anti-AMH antibody is suitable to detect AMH in samples from Human. It has been validated for IHC.

Quick Overview for AMH antibody (C-Term) (ABIN7860738)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AMH antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AMH-7354

Product Details anti-AMH Antibody

Binding Specificity: AA 460-560, C-Term

Purpose: Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS) Antibody

Specificity: The transforming growth factor ≤(TGF≤) superfamily is composed of numerous growth and differentiation factors, including TGF≤1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin ±,≤-A, ≤-B and ≤-C, Lefty and Nodal. Members of the TGF≤superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Alternative Name: Anti Mullerian Hormone

Background:

Muellerian inhibiting factor (MIF)

Human or mouse ovary tissue.

Molecular Weight: 70kDa (reduced), 140kDa (nonreduced)

Gene ID: 268, 112432

Pathways: Negative Regulation of Hormone Secretion