Recombinant Parvin, beta antibody (N-Term)

Catalog No. ABIN7860822

The Rabbit Monoclonal anti-Parvin, beta antibody is suitable to detect Parvin, beta in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant Parvin, beta antibody (N-Term) (ABIN7860822)

Target: Parvin, beta (PARVB)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Parvin, beta antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PARVB-8214R

Product Details anti-Parvin, beta Antibody

Binding Specificity: AA 1-91, N-Term

Purpose: Recombinant Beta-Parvin Antibody

Specificity: Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILKbinding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: N-terminal region (residues 1-91) of human b-parvin

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Parvin, beta

Target: Parvin, beta (PARVB)

Alternative Name: Beta-Parvin

Background:

Affixin, beta-parvin, CGI-56, Parvb

HeLa cell lysate. HeLa cells. Human stomach.

Molecular Weight: 41kDa

Gene ID: 29780, 475074

UniProt: Q9HBI1