CREB5 antibody

Catalog No. ABIN7863650

The Mouse Monoclonal anti-CREB5 antibody is suitable to detect CREB5 in samples from Human. It has been validated for WB, IF and FACS.

Quick Overview for CREB5 antibody (ABIN7863650)

Target: CREB5 (CAMP Responsive Element Binding Protein 5 (CREB5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CREB5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-CREB5-1G8

Product Details anti-CREB5 Antibody

Purpose: CREB5 / CRE-BPa Antibody

Specificity: The ATF/CREB family consists of a series of transcription factors that function by binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2 (also designated ATF-4), CRE-BPa, LZIP (also designated CREB-3 and Luman), CREM-2, ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 and ATF-7. These transcription factors share terminal leucine zipper dimerization and basic DNA binding domains and are highly variable in their N-termini. Although each of the ATF/ CREB proteins bind CREs in their homodimeric form, they can also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. Protein kinase A- mediated CREB phosphorylation induces association with a nuclear protein designated CBP (CREB-binding protein), which may represent a CREB coactivator. CRE-BPa is a nuclear protein that binds DNA as a homodimer but can also form a heterodimer with ATF-2 or Jun.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human CREB5 protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CREB5

Target: CREB5 (CAMP Responsive Element Binding Protein 5 (CREB5))

Alternative Name: CREB5

Background:

cAMP response element-binding protein CREBPa (CRE-BPa), cAMP responsive element binding protein 5 isoform alpha, CRE BPA, CREBPA, cyclic AMP responsive element binding protein 5

HeLa, U87 or K562 cells.

Molecular Weight: 57kDa

Gene ID: 9586, 437075

UniProt: Q02930

Pathways: Thyroid Hormone Synthesis