Recombinant Desmoglein 1 antibody

Catalog No. ABIN7863839

The Rabbit Monoclonal anti-Desmoglein 1 antibody is suitable to detect Desmoglein 1 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant Desmoglein 1 antibody (ABIN7863839)

Target: Desmoglein 1 (DSG1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DSG1-8576R

Product Details anti-Desmoglein 1 Antibody

Purpose: Recombinant Desmoglein-1 (DSG1) Antibody

Specificity: Recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Ç 79oΩDesmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Ç 79oΩWithin the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human DSG1 protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Desmoglein-1

Background:

Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1

Bladder|skin or melanoma.

Molecular Weight: 150kDa (precursor), 160kDa (mature)

Gene ID: 1828, 2633

UniProt: Q02413

Pathways: Cell-Cell Junction Organization