Recombinant RCAS1 antibody

Catalog No. ABIN7863774

This Mouse Monoclonal antibody specifically detects RCAS1 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant RCAS1 antibody (ABIN7863774)

Target: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RCAS1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: REBAG9-7264

Product Details anti-RCAS1 Antibody

Purpose: Recombinant RCAS1 / Estrogen Receptor Binding Site Associated, Antigen 9 Antibody

Specificity: EBAG9, also known as RCAS1, is an estrogen-transcribed protein. Soluble and membranous RCAS1 proteins may play a role in the immune escape of tumor cells by promoting T lymphocyte inhibition of growth and apoptosis. RCAS1 is expressed in a wide variety of cancers, including uterine, ovarian, and lung cancer cells, and acts as a ligand for a putative receptor present on peripheral lymphocytes. RCAS1 is highly expressed not only in cancer cells but also in non-tumor bile duct cells subject to immune attack. RCAS1 inhibits the in vitro growth of receptor-expressing cells and induces apoptosis, contributing to the ability of tumor cells to evade host immune surveillance. High expression of RCAS1 significantly correlates with tumor progression and with poor outcome for many cancer patients.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human EBAG9 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for RCAS1

Target: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Alternative Name: RCAS1

Background:

BAG9, cancer associated surface antigen, cancer associated surface antigen RCAS1, EB9, estrogen receptor binding fragment associated gene 9, PDAF, receptor binding cancer antigen expressed on SiSo cells

Jurkat or HEK-293 cell lysates. Human skeletal muscle tissue.|MCF-7

Molecular Weight: 32kDa

Gene ID: 9166, 409368

UniProt: O00559