Fetuin antibody
The Mouse Monoclonal anti-Fetuin antibody is suitable to detect Fetuin in samples from Human. It has been validated for IHC.
Catalog No. ABIN7861308
$317.38
Plus shipping costs $50.00
20 μg
Shipping to:
United States
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Quick Overview for Fetuin antibody (ABIN7861308)
Target
Fetuin
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Conjugate
This Fetuin antibody is un-conjugated
Application
Immunohistochemistry (IHC)
Clone
AHSG-3748
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Purpose
- Fetuin / AHSG (alpha 2-HS glycoprotein) Antibody
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Specificity
- Fetuin (also designated °™2-z-globulin or °™2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.
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Purification
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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Immunogen
- Recombinant fragment of human AHSG protein (exact sequence is proprietary)
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Isotype
- IgG1, kappa
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 200 μg/mL
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Buffer
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Expiry Date
- 24 months
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- Fetuin
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Background
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59 kDa bone sialic acid-containing protein, Aa2-066, AHS, A-2-HS-glycoprotein chain B, Alpha-2-Z-globulin, HSGA Asialofetuin, Ba-alpha-2-glycoprotein, BSP, Countertrypin, Fetua, Fetuin A, Glycoprotein PP63
Human liver, kidney, testisor placenta
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Molecular Weight
- 59kDa
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Gene ID
- 197, 324746
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UniProt
- P02765
Target
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