Recombinant GATA3 antibody

Catalog No. ABIN7865077

The Mouse Monoclonal anti-GATA3 antibody (Clone rGATA3-9133) (ABIN7865077) specifically detects GATA3 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant GATA3 antibody (ABIN7865077)

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GATA3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RGATA3-9133

Product Details anti-GATA3 Antibody

Purpose: Recombinant GATA-3 (Breast and Urothelial Marker) Antibody

Specificity: GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67 % of urothelial Carcinomas, but none of prostate or renal carcinomas.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around 200-300) of human GATA-3 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for GATA3

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Alternative Name: GATA-3

Background:

GATA3, GATA binding protein-3, GATA-binding factor 3, GATA3, HDR, HDRS, Transacting T-cell-specific transcription factor GATA-3

Human breast or urothelial carcinoma tissue.

Molecular Weight: 50kDa

Gene ID: 2625, 524134

UniProt: P23771

Pathways: Hormone Transport, Regulation of Hormone Metabolic Process, Tube Formation