Recombinant IgD antibody

Catalog No. ABIN7861492

The Rabbit Monoclonal anti-IgD antibody (Clone IGHD-2730R) (ABIN7861492) specifically detects IgD in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant IgD antibody (ABIN7861492)

Target: IgD

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This IgD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: IGHD-2730R

Product Details anti-IgD Antibody

Purpose: Recombinant IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker) Antibody

Specificity: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with é 79oΩ heavy chains and either é 79oΩ or é 79oΩ light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human IGHD protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for IgD

Target: IgD

Alternative Name: IGHD

Background:

Ig delta chain C region, IGHD, Immunoglobulin heavy constant delta

Human tonsil lysate or NAMALWA cell lysate. Human tonsil and lymphoid tissues. Human Serum

Molecular Weight: 44-80kDa (heavy chain), 21-25kDa (kappa light chain)

Gene ID: 3495, 510635

UniProt: P01880