IgD antibody

Catalog No. ABIN7864008

This Mouse Monoclonal antibody specifically detects IgD in IHC. It exhibits reactivity toward Human.

Quick Overview for IgD antibody (ABIN7864008)

Target: IgD

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IgD antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IGHD-4967

Product Details anti-IgD Antibody

Purpose: IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker) Antibody

Specificity: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with t heavy chains and either é 79oΩ or é 79oΩ light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Full-length human IGHD protein

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IgD

Target: IgD

Alternative Name: IGHD

Background:

Ig delta chain C region, IGHD, Immunoglobulin heavy constant delta

Human tonsil lysate, NAMALWA cell lysate, Human tonsil and lymphoid tissues

Molecular Weight: 44-80kDa (heavy chain), 21-25kDa (kappa light chain)

Gene ID: 3495, 510635