Recombinant KRT17 antibody

Catalog No. ABIN7861579

The Rabbit Monoclonal anti-KRT17 antibody (Clone KRT17-8346R) (ABIN7861579) specifically detects KRT17 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant KRT17 antibody (ABIN7861579)

Target: KRT17 (Keratin 17 (KRT17))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This KRT17 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KRT17-8346R

Product Details anti-KRT17 Antibody

Purpose: Recombinant Cytokeratin 17 (CK17) (Basal Epithelial Marker) Antibody

Specificity: CK17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands 79oΩsuch as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human KRT17 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for KRT17

Target: KRT17 (Keratin 17 (KRT17))

Alternative Name: Cytokeratin 17

Background:

K17, Keratin Type I Cytoskeletal 17, Keratin-17, KRT17, PCHC1

bladder or cervix.|T24 cells. Human skin

Molecular Weight: 46kDa

Gene ID: 3872, 2785

UniProt: Q04695