MPZ antibody

Catalog No. ABIN7861785

The Mouse Monoclonal anti-MPZ antibody is suitable to detect MPZ in samples from Human. It has been validated for IHC.

Quick Overview for MPZ antibody (ABIN7861785)

Target: MPZ (Myelin Protein Zero (MPZ))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MPZ antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MPZ-7389

Product Details anti-MPZ Antibody

Purpose: Myelin Protein Zero / MPZ Antibody

Specificity: Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50 % of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human MPZ protein

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: Myelin Protein Zero

Background:

Charcot Marie Tooth neuropathy 1B, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, Myelin protein P0, Myelin protein zero, MYP0_HUMAN, P0

Peripheral nerve cells.

Molecular Weight: 28kDa

Gene ID: 4359, 591486

UniProt: P25189