NPPB antibody

Catalog No. ABIN7863196

The Mouse Monoclonal anti-NPPB antibody is suitable to detect NPPB in samples from Human. It has been validated for IHC.

Quick Overview for NPPB antibody (ABIN7863196)

Target: NPPB (Natriuretic Peptide Precursor B (NPPB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NPPB antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: NPPB-4493

Product Details anti-NPPB Antibody

Purpose: Natriuretic Peptide B / NPPB Antibody

Specificity: Natriuretic peptides comprise a family of three structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. These peptides possess potent natriuretic, diuretic and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. ANP, BNP and CNP are highly homologous within the 17-residue ring structure formed by an intramolecular disulfide linkage. The genes which encode for ANP and BNP map to human chromosome 1p36.22. The gene which encodes for CNP maps to human chromosome 2q37.1.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human NPPB (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for NPPB

Target: NPPB (Natriuretic Peptide Precursor B (NPPB))

Alternative Name: Natriuretic Peptide B

Background:

Brain natriuretic peptide 32, Brain type natriuretic peptide, Gamma brain natriuretic peptide, Natriuretic peptide B, Natriuretic peptide precursor B, natriuretic peptide, brain type, Natriuretic peptides B, natriuretic protein, NPPB

Human heart, liver or uterus.

Molecular Weight: 25-36kDa (glycosylated BNP precursor), 12kDa (deglycosylated mature BNP)

Gene ID: 4879

UniProt: P16860

Pathways: Hormone Activity