Recombinant Periostin antibody

Catalog No. ABIN7864955

This Rabbit Monoclonal antibody specifically detects Periostin in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant Periostin antibody (ABIN7864955)

Target: Periostin (POSTN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Periostin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: POSTN-8951R

Product Details anti-Periostin Antibody

Purpose: Recombinant Periostin (POSTN) Antibody

Specificity: Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for ±V≤3 and ±V≤5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor ≤ 1 (TGF ≤ 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human POSTN protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Periostin

Target: Periostin (POSTN)

Alternative Name: Periostin

Background:

Fasciclin-I like, Osteoblast specific factor 2 (OSF2), PDLPOSTN, Periodontal ligament specific periostin, Periostin isoform thy2 / th4 / thy6 / thy8, Periostin osteoblast specific factor, PN, POSTN

breast or colon tissue.|Human placenta

Molecular Weight: 84/74kDa (Periostin), 90kDa (secreted glycoprotein)

Gene ID: 10631, 136348, 721018

UniProt: Q15063