LMYC antibody

Catalog No. ABIN7863177

This Mouse Monoclonal antibody specifically detects LMYC in WB, ELISA, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for LMYC antibody (ABIN7863177)

Target: LMYC (MYCL) (Protein L-Myc (MYCL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LMYC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-MYCL-2D5

Product Details anti-LMYC Antibody

Purpose: L-Myc / MYCL1 (Transcription Factor) Antibody

Specificity: Oncogene-encoded proteins c-Myc, N-Myc, and L-Myc function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors, the N-Myc gene in neuroblastomas, and the L-Myc gene in human small cell lung carcinomas. c-Myc protein is a transcription factor localized to the nucleus of the cell. It seems to be involved in activating the transcription of growth-related genes. c-Myc binds to DNA during transcription as a heterodimeric complex with Max. c-Myc is phosphorylated in vitro by p44/42 MAP kinase at Ser62 and in vivo at both Thr58 and Ser62. Mutation of Thr58 and Ser62 to Ala inhibits the ability of c-Myc to activate transcription.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human MYCL protein

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for LMYC

Target: LMYC (MYCL) (Protein L-Myc (MYCL))

Alternative Name: L-Myc

Background:

bHLHe38, Class E basic helix-loop-helix protein 38, l myc 1 proto-oncogene, Myc related gene from lung cancer, oncogene lmyc, Protein L-Myc-1, v myc avian myelocytomatosis viral oncogene homolog 1 lung carcinoma derived

HeLa cells. Human small cell lung carcinoma.

Molecular Weight: 40.33kDa

Gene ID: 4610, 437922

UniProt: P12524

Pathways: Warburg Effect