SNAPC4 antibody

Catalog No. ABIN7862096

This Mouse Monoclonal antibody specifically detects SNAPC4 in IHC and FACS. It exhibits reactivity toward Human.

Quick Overview for SNAPC4 antibody (ABIN7862096)

Target: SNAPC4 (Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa (SNAPC4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNAPC4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: PCRP-SNAPC4-3A7

Product Details anti-SNAPC4 Antibody

Purpose: SNAPC4 Antibody

Specificity: TATA-box binding protein (TBP) interactions with TBP-associated factors (TAFs) are required for the transcription of RNA polymerases. One particular TBP-TAF complex, snRNA-activating protein complex (SNAPC), is unusual in that it regulates basal transcription of both RNA polymerase II and III by binding specifically to a non-TATA-box proximal sequence element (PSE). SNAPC consists of five subunits of varying size. SNAPC binds to Oct-1 and TBP, which are activators of snRNA and RNA polymerases, respectively. The POU domain of Oct-1 binds to SNAPC 190 and effectively recruits SNAPC to the PSE. The cooperative binding of SNAPC and Oct-1 to their respective sequence elements is mediated by a nucleosome positioned between the two sequence elements. SNAPC 19 mediates the assembly of the subunits to form a functional SNAPC transcription regulator. SNAPC 50 (also designated PTF≤) contains two zinc finger motifs and binds to SNAPC 43 (also designated PTFé 79oΩ) but not SNAPC 45 (PTFé 79oΩ).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human SNAPC4 protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for SNAPC4

Target: SNAPC4 (Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa (SNAPC4))

Alternative Name: SNAPC4

Background:

FLJ13451, PTFalpha, SNAP190

Human tonsil. HeLa or HDLM-2 cells.

Molecular Weight: 200kDa

Gene ID: 6621, 446091

UniProt: Q5SXM2