Tropomyosin antibody

Catalog No. ABIN7862223

The Mouse Monoclonal anti-Tropomyosin antibody is suitable to detect Tropomyosin in samples from Human. It has been validated for IHC.

Quick Overview for Tropomyosin antibody (ABIN7862223)

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tropomyosin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TPM1-4510

Product Details anti-Tropomyosin Antibody

Purpose: Tropomyosin, alpha-1 chain (striated muscle) Antibody

Specificity: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin ± is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length TPM1 protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Tropomyosin

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Alternative Name: Tropomyosin, alpha-1 chain

Background:

Alpha tropomyosin, TM2, CMD1Y, Tropomyosin, skeletal muscle alpha

Human heart.

Molecular Weight: 35-45kDa

Gene ID: 7168, 133892

UniProt: P04268

Pathways: Regulation of Actin Filament Polymerization