LI Cadherin antibody (AA 200-500)

Catalog No. ABIN7862363

This Mouse Monoclonal antibody specifically detects LI Cadherin in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for LI Cadherin antibody (AA 200-500) (ABIN7862363)

Target: LI Cadherin

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LI Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CDH17-2614

Product Details anti-LI Cadherin Antibody

Binding Specificity: AA 200-500

Purpose: Cadherin 17 / LI Cadherin (Gastric Adenocarcinoma Marker) Antibody

Specificity: It recognizes a protein of 120 kDa, which is identified as Cadherin 17 (also known as LI Cadherin). The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

Purification: 200ug/ml of Ab Purified from rabbit anti-serum by Protein A.

Immunogen: Recombinant fragment (around aa200-500) of human Cadherin 17 protein (CDH17) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for LI Cadherin

Target: LI Cadherin

Alternative Name: Cadherin 17

Background:

BILL-cadherin, Cadherin-17, CDH17, HPT-1 cadherin, human intestinal peptide-associated transporter HPT-1, human peptide transporter 1 (HPT-1), Intestinal peptide-associated transporter HPT-1, LI-cadherin (liver-intestine), Liver Cadherin, Liver-intestine cadherin

Human stomach, colon, liver or small intestine. HepG2 or HT29 cells.

Molecular Weight: 92-120kDa

Gene ID: 1015, 591853

UniProt: Q12864