Recombinant CNN1 antibody (AA 1-200)

Catalog No. ABIN7865069

This Mouse Monoclonal antibody specifically detects CNN1 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant CNN1 antibody (AA 1-200) (ABIN7865069)

Target: CNN1 (Calponin 1 (CNN1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CNN1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RCNN1-9164

Product Details anti-CNN1 Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant Calponin-1 (Smooth Muscle Marker) Antibody

Specificity: Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist, a 34 kDa form and a 29 kDa form. Expression of the 29 kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this MAb reacts with only the 34 kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.

Purification: 200ug/ml of recombinant MAb purified by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human CNN1 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CNN1

Target: CNN1 (Calponin 1 (CNN1))

Alternative Name: Calponin-1

Background:

Calponin 1 basic smooth muscle, Calponin H1 smooth muscle, Calponin-1, CNN1, Cnn1, Sm Calp, SMCC

K562 cells. Myoepithelial cells in breast ducts.

Molecular Weight: 34kDa

Gene ID: 1264, 465929

UniProt: P51911