LY75/DEC-205 antibody (AA 1006-1130)

Catalog No. ABIN7863090

The Mouse Monoclonal anti-LY75/DEC-205 antibody (Clone CD205-3720) (ABIN7863090) specifically detects LY75/DEC-205 in IHC. The antibody is reactive with Human samples.

Quick Overview for LY75/DEC-205 antibody (AA 1006-1130) (ABIN7863090)

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LY75/DEC-205 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: CD205-3720

Product Details anti-LY75/DEC-205 Antibody

Binding Specificity: AA 1006-1130

Purpose: CD205 / LY75 / DEC-205 Antibody

Specificity: DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Purification: 200ug/ml of recombinant MAb purified by Protein A/G.

Immunogen: Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for LY75/DEC-205

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Alternative Name: CD205

Background:

C-type lectin domain family 13 member B, CD205 antigen, CLEC13B, DEC205, gp200 MR6, LY75, Lymphocyte antigen 75, Renal Cell Carcinoma (gp200)

Human tonsil, Thymus or Lymph Node.

Molecular Weight: 198kDa

Gene ID: 4065, 100526664, 153563

UniProt: O60449