Recombinant SOX9 antibody (AA 393-508)

Catalog No. ABIN7865527

This Rabbit Monoclonal antibody specifically detects SOX9 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant SOX9 antibody (AA 393-508) (ABIN7865527)

Target: SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SOX9 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MSVA-709R

Product Details anti-SOX9 Antibody

Binding Specificity: AA 393-508

Expression System: HEK-293 Cells

Purpose: Recombinant SOX9 / SRY-box 9 Antibody

Specificity: Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

Purification: Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant humanSOX9 protein fragment (around aa 393-508) (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SOX9

Target: SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))

Alternative Name: SOX9

Background:

Campomelic Dysplasia Autosomal Sex Reversal (CMD1), SRA1, SRXX2, SRY (sex determining region Y) box 9, SRY related HMG box gene 9, Transcription factor SOX9

Colon: A strong SOX9 immunostaining should be seen in epithelial cells of the crypt base.

Molecular Weight: 65kDa

Gene ID: 6662, 647409

UniProt: P48436

Pathways: EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development