Recombinant Elastin antibody

Catalog No. ABIN7865516

The Rabbit Monoclonal anti-Elastin antibody (Clone MSVA-648R) (ABIN7865516) specifically detects Elastin in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant Elastin antibody (ABIN7865516)

Target: Elastin (ELN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Elastin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MSVA-648R

Product Details anti-Elastin Antibody

Expression System: HEK-293 Cells

Purpose: Recombinant Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Antibody

Specificity: Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries.It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticityto the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.

Purification: Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant full-length human Elastin protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Elastin

Target: Elastin (ELN)

Alternative Name: Elastin

Background:

Elastin, ELN, SVAS, Tropoelastin, WBS, WS

Colon: A moderate to strong elastin immunostaining should be seen of fibres in the lamina propria, around smooth muscle cells of the muscularis mucosae, and in blood vessels (subendothelial).

Molecular Weight: 70kDa

Gene ID: 2006, 647061

UniProt: P15502

Pathways: Regulation of Actin Filament Polymerization