CHRNB4 antibody

Catalog No. ABIN7862517

The Rabbit Polyclonal anti-CHRNB4 antibody is suitable to detect CHRNB4 in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for CHRNB4 antibody (ABIN7862517)

Target: CHRNB4 (Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNB4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHRNB4 Antibody

Purpose: Rabbit Anti-ACHB4 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ACHB4 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human ACHB4 protein at AA range: 300-380

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CHRNB4

Target: CHRNB4 (Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4))

Alternative Name: ACHB4

Background: Neuronal acetylcholine receptor subunit beta-4CHRNB4 (Cholinergic Receptor Nicotinic Beta 4 Subunit) is a Protein Coding gene. Diseases associated with CHRNB4 include Substance Dependence and Nicotine Dependence, Protection Against. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Nicotine Activity on Chromaffin Cells. CHRNB4 is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor.

Molecular Weight: 54kD

Gene ID: 1143

UniProt: P30926