OPRL1 antibody

Catalog No. ABIN7862541

The Rabbit Polyclonal anti-OPRL1 antibody is suitable to detect OPRL1 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for OPRL1 antibody (ABIN7862541)

Target: OPRL1 (Opiate Receptor-Like 1 (OPRL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPRL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-OPRL1 Antibody

Purpose: Rabbit Anti-OPRX Polyclonal Antibody

Specificity: The antibody detects endogenous levels of OPRX protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human OPRX protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for OPRL1

Target: OPRL1 (Opiate Receptor-Like 1 (OPRL1))

Alternative Name: OPRX

Background: Nociceptin receptor, Kappa-type 3 opioid receptor, KOR-3, Orphanin FQ receptorThe protein encoded by OPRL1 is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between OPRL1 and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for OPRL1. A recent study provided evidence for translational readthrough in OPRL1 and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Molecular Weight: 40kD

Gene ID: 4987

UniProt: P41146