CD276 antibody (PE)

Catalog No. ABIN7867152

The Mouse Monoclonal anti-CD276 antibody is suitable to detect CD276 in samples from Human. It has been validated for FACS.

Quick Overview for CD276 antibody (PE) (ABIN7867152)

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 7-517

Product Details anti-CD276 Antibody (PE)

Purpose: Anti-Human CD276- PE Conjugated Monoclonal Antibody (Clone: 7-517)

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: monocyte-derived dendritic cells

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Buffer: Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light,Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background:

Synonyms: B7H3, B7RP-2

Target Background:   Specificity: The mouse monoclonal antibody 7-517 recognizes an extracellular epitope of human CD276 (B7H3) transmembrane glycoprotein. Background: CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells, osteoblasts, sinonasal epithelium, and upon activation (by inflammatory cytokines) in monocytes, NK cells, T cells and B cells. Although it has been described also as a costimulatory ligand, its major role seems to be inhibitory. It regullates T cell proliferation and functions, and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow, which is the primary site of neuroblastoma relapse. CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells, osteoblasts, sinonasal epithelium, and upon activation (by inflammatory cytokines) in monocytes, NK cells, T cells and B cells. Although it has been described also as a costimulatory ligand, its major role seems to be inhibitory. It regullates T cell proliferation and functions, and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow, which is the primary site of neuroblastoma relapse.

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints