Recombinant Gastrin antibody (AA 1-101)

Catalog No. ABIN7867908

The Rabbit Monoclonal anti-Gastrin antibody is suitable to detect Gastrin in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Gastrin antibody (AA 1-101) (ABIN7867908)

Target: Gastrin (GAST)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Gastrin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GAST-8646R

Product Details anti-Gastrin Antibody

Binding Specificity: AA 1-101

Purpose: Recombinant Gastrin Antibody

Purification: Protein A affinity

Immunogen: A portion of amino acids 1-101 from human GAST protein was used as the immunogen for the recombinant Gastrin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Gastrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Gastrin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Gastrin

Target: Gastrin (GAST)

Alternative Name: Gastrin

Background: Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.

UniProt: P01350