alpha KGDHC antibody (AA 1-1023)

Catalog No. ABIN7867921

The Rabbit Polyclonal anti-alpha KGDHC antibody (ABIN7867921) specifically detects alpha KGDHC in WB, ELISA and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for alpha KGDHC antibody (AA 1-1023) (ABIN7867921)

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha KGDHC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-alpha KGDHC Antibody

Binding Specificity: AA 1-1023

Purpose: OGDH Antibody / 2-oxoglutarate dehydrogenase

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-S1023) was used as the immunogen for the OGDH antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the OGDH antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the OGDH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for alpha KGDHC

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Alternative Name: OGDH

Background: Alpha-ketoglutarate dehydrogenase also known as 2-oxoglutarate dehydrogenase E1 component, mitochondrial is an enzyme that in humans is encoded by the OGDH gene. This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[

UniProt: Q02218