Glutaredoxin 1 antibody (AA 1-106)

Catalog No. ABIN7867933

The Rabbit Polyclonal anti-Glutaredoxin 1 antibody (ABIN7867933) specifically detects Glutaredoxin 1 in WB, ELISA, IF, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Glutaredoxin 1 antibody (AA 1-106) (ABIN7867933)

Target: Glutaredoxin 1 (GRX1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Glutaredoxin 1 Antibody

Binding Specificity: AA 1-106

Purpose: GLRX Antibody / Glutaredoxin 1

Purification: Antigen affinity purified

Immunogen: A human recombinant partial protein (amino acids M1-Q106) was used as the immunogen for the GLRX antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GLRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GLRX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Glutaredoxin 1

Target: Glutaredoxin 1 (GRX1)

Alternative Name: GLRX

Background: GLRX (Glutaredoxin 1) is a small redox enzyme that belongs to the thioredoxin family and plays an essential role in maintaining cellular redox homeostasis. It catalyzes the reversible reduction of protein disulfides and mixed disulfides formed between proteins and glutathione, a process known as deglutathionylation. This activity regulates protein function, protects against oxidative stress, and ensures proper signal transduction. Researchers frequently use a GLRX antibody to investigate antioxidant defense systems, redox regulation, and stress responses.

GLRX is widely expressed in mammalian tissues, with particularly high levels in heart, liver, and skeletal muscle. Its enzymatic activity is critical in pathways that counteract oxidative damage and maintain the thiol status of proteins. Dysregulation of GLRX has been linked to cardiovascular disease, neurodegenerative disorders, and cancer, where imbalances in redox signaling contribute to disease pathology. Employing a GLRX antibody allows scientists to analyze protein expression, localization, and post-translational modifications in health and disease.

In addition to its protective role, GLRX has been implicated in apoptosis, inflammatory responses, and mitochondrial function. It also interacts with iron-sulfur cluster proteins, influencing mitochondrial biogenesis and energy metabolism. Because oxidative stress is a common hallmark of many diseases, GLRX remains an attractive target for translational research. Using a GLRX antibody provides a reliable approach for monitoring its activity and contribution to cellular redox control.

NSJ Bioreagents provides a high-quality GLRX antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a GLRX antibody from NSJ Bioreagents ensures consistent performance and reproducibility in studies of oxidative stress, redox regulation, and disease mechanisms.

UniProt: P35754

Pathways: Cell RedoxHomeostasis