PVALB antibody (AA 1-110)

Catalog No. ABIN7867943

This Mouse Monoclonal antibody specifically detects PVALB in IHC (p). It exhibits reactivity toward Human.

Quick Overview for PVALB antibody (AA 1-110) (ABIN7867943)

Target: PVALB (Parvalbumin (PVALB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVALB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: PVALB-7601

Product Details anti-PVALB Antibody

Binding Specificity: AA 1-110

Purpose: Parvalbumin Antibody / PVALB (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-110) from the human protein was used as the immunogen for the Parvalbumin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Parvalbumin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Parvalbumin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PVALB

Target: PVALB (Parvalbumin (PVALB))

Alternative Name: Parvalbumin

Background: The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100Alpha and beta, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin Alpha and parvalbumin beta, also designated oncomodulin (OCM). Structurally and evolutionarily conserved, parvalbumin Alpha and OCM proteins are distinct in expression and function. Parvalbumin Alpha, also designated parvalbumin (PV), is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues, including kidney and parathyroid. Research indicates that parvalbumin Alpha plays a significant role in muscle relaxation. OCM was originally thought to have expression restricted to neoplastic tissues, early embryonic cells and certain tumor cell lines. Recent research shows that OCM is also expressed and secreted by macrophages where, in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration. OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals. In humans, two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951). These genes encode proteins 109 amino acids in length which share 99 % sequence identity.

UniProt: P20472