Recombinant Calcitonin antibody (AA 1-141)

Catalog No. ABIN7868140

The Rabbit Monoclonal anti-Calcitonin antibody (Clone CALCA-8639R) (ABIN7868140) specifically detects Calcitonin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Calcitonin antibody (AA 1-141) (ABIN7868140)

Target: Calcitonin (Calca)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Calcitonin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CALCA-8639R

Product Details anti-Calcitonin Antibody

Binding Specificity: AA 1-141

Purpose: Calcitonin Antibody / CALCA / CGRP

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human Calcitonin protein (around aa 1-141) was used as the immunogen for the Calcitonin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Calcitonin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Calcitonin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Calcitonin

Target: Calcitonin (Calca)

Alternative Name: Calcitonin

Background: Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or Alpha-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or Beta-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.

UniProt: P01258