SIVA1 antibody (AA 1-141)

Catalog No. ABIN7868145

The Rabbit Polyclonal anti-SIVA1 antibody is suitable to detect SIVA1 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for SIVA1 antibody (AA 1-141) (ABIN7868145)

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIVA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-SIVA1 Antibody

Binding Specificity: AA 1-141

Purpose: SIVA1 Antibody / CD27BP

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-T141) was used as the immunogen for the SIVA1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SIVA1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SIVA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Alternative Name: SIVA1

Background: Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis.

UniProt: O15304

Pathways: Positive Regulation of Endopeptidase Activity