CDC5L antibody (AA 1-148)

Catalog No. ABIN7868175

The Mouse Monoclonal anti-CDC5L antibody is suitable to detect CDC5L in samples from Human. It has been validated for FACS and IHC (p).

Quick Overview for CDC5L antibody (AA 1-148) (ABIN7868175)

Target: CDC5L (CDC5 Cell Division Cycle 5-Like (S. Pombe) (CDC5L))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDC5L antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PCRP-CDC5L-2C6

Product Details anti-CDC5L Antibody

Binding Specificity: AA 1-148

Purpose: CDC5L Antibody / Cell division cycle 5-like protein

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-148) from the human protein was used as the immunogen for the CDC5L antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the CDC5L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CDC5L antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDC5L

Target: CDC5L (CDC5 Cell Division Cycle 5-Like (S. Pombe) (CDC5L))

Alternative Name: CDC5L

Background: Cdc5L (cell division cycle 5-like protein, pombe Cdc5-related protein) is a DNA-binding protein encoded by the human gene CDC5L. Cdc5L contains two HTH Myb-type DNA-binding domains and may shuttle between cytoplasm and nucleus. It is involved in cell cycle control and may act as a transcription activator. Cdc5L is a spliceosomal protein that is highly conserved across species. It belongs to the group of proteins that comprise the core of spliceosomal complexes and are essential for pre-mRNA splicing. Cdc5L is involved in the second catalytic step of pre-mRNA splicing, which involves cleavage at the 3' splice site and the ligation of the exons. This process releases the intact intron lariat. A chromosomal aberration involving Cdc5L is found in multicystic renal dysplasia. This aberration is caused by a translocation (t 6,19,p21,q13.1) with USF-2.

UniProt: Q99459

Pathways: Activation of Innate immune Response, Chromatin Binding