LMO2 antibody (AA 1-159)

Catalog No. ABIN7868222

This Rabbit Polyclonal antibody specifically detects LMO2 in WB and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for LMO2 antibody (AA 1-159) (ABIN7868222)

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMO2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LMO2 Antibody

Binding Specificity: AA 1-159

Purpose: Danre Lmo2 Antibody / Rhombotin 2

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived Danre Lmo2 recombinant protein (amino acids M1-V159) was used as the immunogen for the Danre Lmo2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Danre Lmo2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Danre Lmo2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LMO2

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Alternative Name: Lmo2

Background: Lmo2, or LIM domain only protein two, is a transcriptional regulator that plays a critical role in hematopoietic and vascular development. In zebrafish, Lmo2 is essential for the specification of blood and endothelial lineages and is widely used as a molecular marker for early hematopoietic progenitor cells.

Lmo2 does not directly bind to DNA but functions as a scaffold protein, forming complexes with other transcription factors to regulate gene expression. During zebrafish embryogenesis, Lmo2 is expressed in the intermediate cell mass, the site of primitive blood cell formation, and in the developing vasculature. It is required for the emergence of both erythroid and myeloid lineages, as well as for the proper development of endothelial cells.

Loss of Lmo2 function in zebrafish results in severe defects in blood cell formation and vascular patterning, highlighting its central role in mesodermal differentiation. Because of its strong evolutionary conservation and defined expression patterns, zebrafish Lmo2 serves as a powerful model for studying hematopoiesis, angiogenesis, and transcriptional networks involved in early development.

Lmo2 is also relevant to human health, as misregulation of Lmo2 has been associated with leukemia. This makes zebrafish Lmo2 a valuable tool in both basic research and disease modeling related to blood development and cancer biology.

UniProt: Q9PTJ3

Pathways: Chromatin Binding